Science
Breaking the Undruggable: A Small Molecule Rewires Cancer Immunity
The Aged Brain Rewrites Its Own Immune Cells, Study Finds
Immune Cells Programmed to Attack Mitochondria Trigger Parkinson's Disease in Mice
Cancer Biology
When Oncogenes Go Dark: How Cancer Silences Its Own Drivers
A new study reveals that cancer cells harboring extrachromosomal DNA are predisposed to a form of genomic misfiling that paradoxically shuts down the very oncogenes driving their growth.. The mechanism involves damaged DNA, collective mis-segregat...
Cancer's Rulebook, Rewritten: A Landmark Framework Gets Its Decade Update
A decade after proposing six core capabilities that define malignancy, Douglas Hanahan and Robert Weinberg have returned with a more complete map of how cancer works — one that adds metabolism, immunity, and the tumor's hidden ecosystem to the equ...
A Stemness Score Tracks Prostate Cancer From Diagnosis to Lethal Disease
A new study spanning 87,000 tumor samples proposes that a single molecular score, measuring how 'stem-like' a cancer cell has become, can track prostate cancer from its earliest stages to its most lethal form and predict which patients will die fr...
Cancer Immunology
Cancer's Hidden Shield: How Stressed Tumors Corrupt the Immune System
A protein secreted by stressed cancer cells has been caught sabotaging the immune system from within, corrupting the very macrophages that should be sounding the alarm.
Breaking the Undruggable: A Small Molecule Rewires Cancer Immunity
For decades, protein phosphatases were written off as targets too chemically hostile to drug.. A new compound challenges that verdict, and the results in preclinical cancer models are striking.
Chemical Biology
Seeing the Cell, Not the Molecule: How Microscopy Images Are Reshaping Drug Discovery
For decades, the search for new medicines has begun with a simple assumption: that molecules resembling a known drug will behave like one.. A new study of 112,480 compounds suggests that assumption has been costing us discoveries.
Neuroscience
A Repurposed Antipsychotic Silences Seizures in Human Brain Tissue
Surgically removed brain tissue from patients with drug-resistant epilepsy continued to fire in rhythmic, seizure-like bursts in the laboratory dish.. Then researchers added prochlorperazine, a decades-old antinausea drug, and the electrical storm...
Young Blood Reverses Cognitive Aging in Mice, Pointing to a Molecular Fountain of Youth
A series of experiments connecting old mice to young circulatory systems has produced something that aging research rarely delivers: a reversal.. Not a slowing, not a prevention, but a genuine rolling-back of cognitive decline already in progress.
Drug Discovery
Seeing the Cell: How Microscopy Images Are Reshaping Drug Discovery at Scale
For decades, chemists have searched for new drugs by looking for molecules that resemble ones that already work.. A new study argues that approach is leaving too much on the table, and that the answer lies not in chemical structure, but in what a ...
Immunology
The Janus Cell: A Peripheral Sentinel That Mirrors the Thymus
Deep in the lymph nodes, a newly discovered immune cell quietly patrols for self-reactive T cells that slipped past the thymus.. It borrows its toolkit from two different lineages and, against all expectation, looks almost exactly like the thymic ...